Update on KSHV epidemiology, Kaposi Sarcoma pathogenesis, and treatment of Kaposi Sarcoma
نویسندگان
چکیده
منابع مشابه
Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an update.
Kaposi sarcoma-associated herpesvirus (KSHV) is the etiological agent of several human malignancies. The virus is able to modulate pro-proliferative pathways to its advantage, while simultaneously inhibiting pro-apoptotic signaling pathways. These functions are carried out by multiple viral proteins acting in concert. The overall outcome is the survival and proliferation of the infected cell. A...
متن کاملKaposi sarcoma herpesvirus pathogenesis
Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a phylogenetically old human virus that co-evolved with human populations, but is now only common (seroprevalence greater than 10%) in sub-Saharan Africa, around the Mediterranean Sea, parts of South America and in a few ethnic communities. KSHV causes three human malignancies, Kaposi sarcoma, primary effusion lymp...
متن کاملKaposi sarcoma: review and medical management update.
Despite recent advances in our understanding of pathogenic mechanisms involved, the true nature of Kaposi sarcoma remains an enigma. Four clinical variants have been described for the disease, differing in natural history, site of predilection, and prognosis. All forms of Kaposi sarcoma may manifest in the oral cavity and Kaposi sarcoma-associated virus appears essential to development of all c...
متن کاملEpidemiology, Pathophysiology, and Treatment of Kaposi Sarcoma–Associated Herpesvirus Disease: Kaposi Sarcoma, Primary Effusion Lymphoma, and Multicentric Castleman Disease
Ryan J. Sullivan, Liron Pantanowitz, Corey Casper, Justin Stebbing, and Bruce J. Dezube Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, and Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts; Departments of Medicine and Epidemiology, University of Washington, and Vaccine and...
متن کاملKaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.
Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the gamma-herpesvirinae subfamily. KSHV has been associated with the development of three neoplastic diseases: Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). In this review, we discuss the three KSHV-associated malignancies, KSHV genome, latent and lyti...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2011
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2011.02.006